Running QBs of any size eventually start having a string of injuries. The one exception seems to be Russel Wilson..... for now. But that guy has taken a lot of hits in his career and it just seems inevitable that they will mount up.
This is why the Lamar Jackson experiment is so risky. Even the giant Cam Newton has gone through phases of running vs. not running. Problem is, when he runs a lot, his game improves but he gets hurt. When he doesn't run, his game declines but he stays healthy. Wentz can't stay healthy and I say his game is similar to Newton; if he tries to become a pure pocket QB ala Brady or Goff in order to try to keep more healthy, his game will suffer. He is intrinsically wired to run.
Michael Vick..... a bit bigger and faster than Murray.... just had a heck of a time staying healthy.
So, as of now, it has yet to be proven that over the long haul that a QB where running is an integral part of his game can survive injury. The game just isn't played in a way that running QBs can thrive beyond a year or so..... to when D's get plenty of film and catch up to them. The NFL in some ways doesn't help matters in that when a QB runs the ball he effectively becomes a RB.... except for the feet first give-up. And no matter where these running QBs go to college there is no comparable situation with the size, speed, strength of the D players, and to the complexities of the NFL DCs game plans.
But.... that doesn't seem to keep NFL teams from trying and trying and the sports media from constantly claiming that the "new" NFL QB is a running QB and their "darling" QB picks are always "athlete" QBs. Check who has been in and won Superbowls, and you're not going to find very many running QBs because most them just can't survive long enough to get good enough.