I think we know what the "cause" is-if we define "cause" as "origin". It is the torn ACL to the same knee at Georgia and the subsequent surgery. From what I gather it was a major tear and required extensive surgery and lengthy rehabilitation. Had that not happen I doubt were dealing with the inflammation to the same area. Then again he would not have fallen in the draft to the Rams as he likely would have been the Heisman trophy winner.
A statement from Mayo Clinic: "A new Mayo Clinic study found that nerve inflammation may cause the pain, numbness and weakness following surgical procedures that is known as postsurgical neuropathy."
It may be that the running back may have come back and played for the Rams too early. He likely should have taken that initial NFL year off to continue his rehab. The negative outlook is that he may well be facing periodic inflammation to the same area.