UGH! Our cat is missing.

Last saw her about 8:30 last night. I have been at work since 6:30 this AM and my Wife says she never had her breakfast. She NEVER misses a meal. My Wife walked up and down our street, checked the next door neighbor's yard, called other neighbors on the street but no luck. I feel bad because I am at work and my Wife is starting to get really upset. Our cat HAS disappeared for 12-15 hours bur never 24. She is quite chubby and does not roam too far.....usually.