I think center is the "gaping hole" for them right now for the reasons you outline.
Even at DB, yeah, they need to replace Hill (Long?) but when you are starting at CB with Ramsey and Williams you're doing OK... Same at safety where it's a shame Johnson goes but they have Fuller, Burgess, Rapp and Scott all under contract through 2022.
One thing your list made me think about is ILB. On one hand they return Reeder, Kiser, Howard and Young. Fine for 2021. But 3 of those 4 will be UFAs in 2022. So they may very well draft one with an eye on back-filling there for 2022. I doubt it's with any of their first 3 selections but somewhere. And ILB is just an easier position to replace regardless.