It's a RARE qb who can have a day like that behind a crippled OL.
Of course it means nothing if they didn't win. Maybe if the OL were relatively healthy they would have won.
Here's the thing. For years now I have read all these posts talking about how qbs can still play behind broken OLs. --->THE REALITY<-- is that examples of ones who actually have done so is few and far between. Every now and then, someone tries to throw up an exception, and then act like that exception is the rule. And, of course it isn't.
Fact: you cripple an OL and with the vast majority of qbs, they go down with the OL.
So again, great for Mahomes and his numbers. In a losing effort by an exceptional and rare type of qb. Give him a solid OL and maybe they would have beaten the mediocre Titans. Who instead won with a relatively healthy OL and Tannenhill at qb (who threw 19 times for 181 yards.)