Rams are just as likely to win against Patriots as losing to Bills.
Every game is most likely going down in the 4th quarter and will come down to a couple of plays, most likely turnovers.
If Donald and Quinn can continue to create havoc in the backfield, that gives the Rams an advantage, provided the offense doesn't turn over the ball and scores once or twice between all the punting.
But It wouldn't surprise me to see the Rams lose to the Bills, but beat the Patriots. The quality of the opponent doesn't seem to matter.