The Niners want you to run a bunch of stuff behind the LOS and then use their fast flowing D to cut you down for a loss.
Actually the Bucs and the Niners D are similar in their strengths and weaknesses. Excellent front 7, not so good back 4.
Further, it is not a high likelihood to get much out of the running game.... just enough to stay ahead of the sticks most times is sufficient in order to run plenty of play action passing.
I want to see a little more of Sony Michel because he's not only North South, he is very physical and he is very ball secure.