Late 2nd quarter, Jags up 14-3 with the ball at the Patriots' 44. Coming out of a timeout. Jags convert on 3rd down to Patriots 32 but the play is called back on a delay of game (
a delay of game coming off a timeout...). Bortles is sacked on the next play, forced to punt. Patriots drive in 2 minutes to close the gap to 14-10.
That little mistake likely swung the game from 17-3 at halftime to 14-10. The Patriots capitalize on small unforced errors like that like no other. To me the game was lost right there.