After LT, then Center, then OGs.
The thing is, there are viable ways to help OTs with backs chipping, TE's double teaming, etc. The only problem is that when you do, you tend to lose the advantage of running a TE into a pattern.
But on the interior? More difficult. Double teams are hard to do and when you do, you better hope there's not a blitz coming or a stunt.
Plus, the shortest distance between 2 points is a straight line. A DT lining up over a Guard only needs about 3 steps to be in the QBs face. And that tends to ruin everything.
But it is also what makes Donald so devastating. He is through that gap in a flash and at times almost beats the QB to the height of his drop back.