While the changes won't be fundamental, I expect the following:
Watkins is going to get moved around a bit, and likely used in motion in order to get him started. He is simply too much of a playmaker to let languish.
I think Goff will throw him more 50/50 balls on deep routes.
I expect to see Kupp out wide sometimes with Tavon in the slot to give a different look.
I expect to see Pharaoh Cooper given some offensive opportunities. He's proven to be real good with the ball in his hands.
I expect to see Brown get a few more carries. Not only is he productive, but Gurley should not be overworked especially during the 2nd half of the year. Brown won't give you the big play; but he moves the pile, holds on to the ball, and can bull his way for 8, 9, 10 yards.
I expect to see the Rams to operate mostly up tempo, quick lining up after the previous play, as they did with the Cards. It puts the D at a disadvantage and the offense seems to thrive with that style. Goff also seems to thrive in it. It seems to create a nice rhythm.
I expect Sullivan to have his reps decreased and Austin in on meaningful downs even though Sullivan is healthy. Austin has really progressed and it is best to give Sullivan some reps off every game to keep him going. He has really solidified the center of our Oline in the way Whitworth has solidified the Left side.
I see very little change coming on D. Wade has substituted liberally and I expect that to continue.