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Re: okay...

May 10, 2020 04:38PM
Quote
bigjimram21
But with Corona it is a moving target. Some say the SARS vaccine they were working on helped with the one in trials now for Covid. But the lockdown breakout has begun in earnest. Where it will be in a month ,who knows.

The problem with a vaccine is always testing. That takes months. When it comes to that a head start makes no difference.

The lockdown breakout is just going to make more people sick.

Just something I read on testing vaccines. -->

...

Quote

from [www.yahoo.com]

The vaccine trial phases

...the real race to a vaccine starts, with clinical tests on humans. It starts with Phase I, with a few dozen patients, in which you look for the best dose of the vaccine in humans, while observing minimal side effects. It is a safety phase. This Phase I takes various weeks, probably at least two months, because you first need to inject the vaccine to a small number of patients, and wait a week or longer to get results. Then you do the same with another few people, and with a higher dose, and again you wait, and so on, until you get to a target dose you will use for the Phase II and Phase III trials.

Then comes Phase II, with hundreds of patients, to prove the vaccine candidate creates anti-bodies and creates immunity response. This phase uses healthy people who are not necessarily faced with the virus, and it will also take a few months. You probably need to give multiple doses, particularly for the RNA, DNA, vector and recombinant vaccines, because they break down typically before creating strong immunity. You need a 3-4 week interval in between each 'boost', and see how the body reacts (that can take a week or two). So for this phase again you need at least two months, and more probably, three months.

Then comes Phase III, where you do a real test for effectiveness, and protective immunity: can the vaccine immunity protect against the infection for the disease? This is the 'make or break' phase that will determine whether we have an initial 'winner'. But the phase will take even longer, as you'll need to include a lot of people in your trial to know effectiveness: some will get the real vaccine, and others the placebo, and you need to follow them over time to know if there's a difference in infection between the two groups. That, of course, is a problem: many societies have either strict lockdown measures in place (in much of Europe, the Americas, and the Middle East). Or they have very few infections anymore (in China, Korea, Singapore, and other parts of East Asia).

Either way, this phase will easily last six months, and again, possibly (much) longer, and for the front-runners, will likely start in the fall of 2020. When it takes place, you can see two logical candidates for trial groups: people who live in homes for the elderly, where there are a lot of infections, and people who work in the health sector. The the second group is the most logical, because they are healthy and likely to get exposed to the virus. But you will have to make sure to choose those healthcare workers who haven't gotten the virus before.
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SubjectAuthorViewsPosted

  Good news pointing to a possible NFL season come September...

Rams43962May 09, 2020 12:39PM

  Re: Good news pointing to a possible NFL season come September...

BigGame81117May 09, 2020 12:43PM

  Re: I don’t know how any thoughtful person

Speed_Kills163May 09, 2020 01:09PM

  I went out to grocery store for first time in 3.5 weeks

ferragamo79169May 09, 2020 01:17PM

  what!!! that’s nuts

Speed_Kills117May 09, 2020 01:43PM

  Re: what!!! that’s nuts

Classicalwit82May 09, 2020 03:36PM

  Re: I went out to grocery store for first time in 3.5 weeks

bigjimram2192May 09, 2020 01:53PM

  Re: I went out to grocery store for first time in 3.5 weeks

waterfield90May 09, 2020 02:05PM

  Re: I went out to grocery store for first time in 3.5 weeks

zn106May 09, 2020 02:05PM

  Re: I went out to grocery store for first time in 3.5 weeks

waterfield85May 09, 2020 02:12PM

  Re: I went out to grocery store for first time in 3.5 weeks

max72May 09, 2020 03:46PM

  Re: I went out to grocery store for first time in 3.5 weeks

zn75May 09, 2020 04:01PM

  Re: I went out to grocery store for first time in 3.5 weeks

max64May 09, 2020 04:28PM

  Re: I went out to grocery store for first time in 3.5 weeks

zn68May 09, 2020 04:32PM

  Re: I went out to grocery store for first time in 3.5 weeks

max58May 09, 2020 04:39PM

  Re: I went out to grocery store for first time in 3.5 weeks

AlbaNY_Ram51May 09, 2020 05:28PM

  Re: I went out to grocery store for first time in 3.5 weeks

zn72May 09, 2020 05:34PM

  Re: I went out to grocery store for first time in 3.5 weeks Attachments

AlbaNY_Ram72May 09, 2020 06:09PM

  Re: I went out to grocery store for first time in 3.5 weeks

k354May 09, 2020 08:29PM

  Re: I went out to grocery store for first time in 3.5 weeks

zn51May 09, 2020 08:55PM

  Re: I went out to grocery store for first time in 3.5 weeks

Classicalwit46May 09, 2020 04:28PM

  Re: I went out to grocery store for first time in 3.5 weeks

max44May 09, 2020 04:33PM

  Re: I went out to grocery store for first time in 3.5 weeks

zn48May 09, 2020 04:57PM

  Re: I went out to grocery store for first time in 3.5 weeks

max50May 09, 2020 05:04PM

  Re: I went out to grocery store for first time in 3.5 weeks

zn61May 09, 2020 05:21PM

  Re: I went out to grocery store for first time in 3.5 weeks

Classicalwit42May 09, 2020 04:58PM

  Just curious

Suh-weet!74May 09, 2020 05:19PM

  Re: Just curious

zn62May 09, 2020 05:24PM

  It's both my experience and intuition that....

Suh-weet!45May 09, 2020 06:30PM

  Re: hell... what about spreading it

Speed_Kills62May 09, 2020 05:29PM

  Re: hell... what about spreading it

Rampage2K-62May 09, 2020 06:37PM

  Re: hell... what about spreading it

zn57May 09, 2020 06:40PM

  Re: hell... what about spreading it

Classicalwit43May 09, 2020 07:35PM

  Re: I went out to grocery store for first time in 3.5 weeks

MamaRAMa56May 09, 2020 08:57PM

  Re: I went out to grocery store for first time in 3.5 weeks

bigjimram2152May 10, 2020 08:16AM

  okay...

zn78May 10, 2020 08:22AM

  Re: okay...

bigjimram2135May 10, 2020 04:08PM

  Re: okay...

zn39May 10, 2020 04:38PM

  The bigger question

PHDram55May 09, 2020 06:11PM

  LOL my wife went out

ferragamo7936May 11, 2020 05:36AM

  My answer to that

waterfield91May 09, 2020 02:00PM

  Re: Good one Biggame!!!!

oldschoolramfan48May 09, 2020 03:57PM

  Because everyone doesn’t lives their lives in fear

RockRam87May 10, 2020 10:46AM

  Re: Because everyone doesn’t lives their lives in fear

Rampage2K-69May 10, 2020 11:05AM

  Re: Because everyone doesn’t lives their lives in fear

waterfield61May 10, 2020 11:11AM

  how about living in common sense

zn97May 10, 2020 12:06PM

  4 years

PHDram68May 10, 2020 04:14PM

  Re: 4 years

zn61May 10, 2020 04:42PM

  The fastest time to develop a vaccine

PHDram55May 10, 2020 05:06PM

  Re: The fastest time to develop a vaccine

Rampage2K-51May 10, 2020 05:24PM

  I hope your right but

PHDram39May 10, 2020 05:31PM

  Re: I hope your right but

zn53May 10, 2020 06:31PM

  Re: I hope your right but

PHDram36May 10, 2020 10:28PM

  Re: I hope your right but

zn43May 11, 2020 03:56AM

  You misunderstand

PHDram35May 11, 2020 04:23AM

  Re: I hope your right but

MOBSQUAD9912May 18, 2020 12:57PM

  Re: I hope your right but

zn8May 23, 2020 04:54PM

  Re: I hope your right but

ramBRO48May 11, 2020 05:19AM

  Re: I hope your right but

PHDram42May 11, 2020 05:47AM

  Re: I hope your right but

Rams4334May 11, 2020 07:26AM

  Re: I hope your right but

ramBRO39May 11, 2020 08:43AM

  empathy, fear, patience, and understanding.

LMU9355May 11, 2020 10:27AM

  Re: empathy, fear, patience, and understanding.

Rampage2K-31May 11, 2020 10:38AM

  Re: empathy, fear, patience, and understanding.

AlbaNY_Ram10May 24, 2020 04:23AM

  Re: I hope your right but

PHDram28May 11, 2020 01:24PM

  Re: how about living in common sense

bigjimram2154May 10, 2020 04:15PM

  Re: how about living in common sense

zn56May 10, 2020 04:39PM

  No sir. What you want is for everyone to do what what you want

RockRam52May 11, 2020 11:58AM

  Nope and don't get personal

zn49May 11, 2020 12:30PM

  Re: No sir. What you want is for everyone to do what what you want

AlbaNY_Ram46May 11, 2020 01:13PM

  Re: No sir. What you want is for everyone to do what what you want

Rampage2K-39May 11, 2020 01:28PM

  Re: No sir. What you want is for everyone to do what what you want

RAMbler37May 11, 2020 02:07PM

  ramsrule is great

PHDram35May 11, 2020 07:31PM

  Re: ramsrule is great

zn40May 12, 2020 07:01AM

  thanks for your opinion

PHDram25May 12, 2020 07:27AM

  you too (nm)

zn15May 12, 2020 07:34AM

  Illustration of importance of masks Attachments

waterfield12May 23, 2020 03:31PM

  Re: perhaps

AlbaNY_Ram31May 12, 2020 08:31AM

  Re: perhaps

PHDram19May 12, 2020 08:52AM

  Re: No sir. What you want is for everyone to do what what you want

GroundPounder34May 11, 2020 05:22PM

  Re: hypothetical conversatiom

AlbaNY_Ram45May 11, 2020 07:51PM

  ^^^ This right here! ^^^

RAMbler25May 12, 2020 08:20AM

  Re: No sir. What you want is for everyone to do what what you want

waterfield13May 23, 2020 03:21PM

  Re: Good news pointing to a possible NFL season come September...

Classicalwit58May 09, 2020 03:40PM

  Re: Good news pointing to a possible NFL season come September...

ramBRO36May 09, 2020 04:26PM

  Re: Good news pointing to a possible NFL season come September...

Ramsdude38May 09, 2020 04:34PM

  Re: If everyone does not follow the rules, then it's all a waste of time.....

oldschoolramfan55May 09, 2020 04:08PM

  Re: If everyone does not follow the rules, then it's all a waste of time.....

waterfield53May 09, 2020 08:14PM

  Re: Good news pointing to a possible NFL season come September...

SoCalRAMatic64May 10, 2020 04:58AM

  I really wonder how they are gonna open up schools in September

max83May 10, 2020 05:01AM

  One of my many fears!

Ram Fan Teacher57May 11, 2020 08:48AM

  Re: Good news pointing to a possible NFL season come September...

MOBSQUAD9915May 18, 2020 12:58PM