I don't see it happening. The best defense against Kittle are the Niner's themselves and not using him. Which they do occasionally. I have yet to see any team or player that can stop Kittle. If the Niners decide to use him, and use him often, we're in for a long day.... any team is in for a long day if Kittle is the feature guy for the day.
Now to be honest I don't know if Kittle is just that good at getting open or if it's that defenses tend to ignore him... but either way, if the Niner's want to go to him he WILL be open. - JamesJM