The winners will be the ones who get through the playoffs healthy. Kupp always seems to get injured for the postseason. Donald injured his ribs and the Packers were never slowed. The Chiefs lost a couple linemen and couldn't block the Bucs. The Patriots had a perfect season but lost a guard and couldn't block the Giant's front. The only outlier was the Eagles when they had the magic that overcame their injuries.
Losing any of Stafford, Donald, or Ramsey would be catastrophic. Losing Kupp, Henderson, Jones, Allen, or Fuller would greatly reduce their odds. The teams we see today could be markedly different in 9 or more games.