It will certainly be telling in how the Rams approach that. Probably will man him up on either Burgess or whoever they feel they need to use but they also are going to play more zone this year so we'll see.
Honestly beating the 9ers though is all about shutting down that run game. When Garoppolo doesn't have a 5 ypc ground game keeping a defense on its heels you get to see the real QB. And I do think the Rams will play the run well this year, but the 9ers will again be one of the toughest matchups on the ground.