I think given his health, the teams prospects for success and his salary that he will come back. But its definitely not guaranteed. He is doing the smart thing by stepping away for a couple weeks.
With Noteboom, personally I would rather see Blythe slide over to center and have him start at RG next year.
With or without Saffold they should draft another interior OL with one of their 3rd round picks. I do think Saffold returns though. He wont take a lowball but I dont see him pushing for top $.