I don't know what he's showing in practice, but I might start Kiser next to Barron and move Littleton outside to pair with Fowler.
I'd be giving up some size on the outside but potentially shoring up the inside run defense. Ekuban & Longacre don't appear to be effective starters at either run defense or pass rush, so let's shake things up.

Our DL is all up-field rushes, as are our outside guys. That leaves 2 undersized "swiss army knife" guys to handle the run, and it's not working. Maybe Kiser can take away the run. Take away the run and you take away the the play-action, which might help our defensive backfield.