With Bosa, Hargrave, Greenlaw, and Warner entering the game with seek and kill orders against Stafford, we'll need an abundance of two TE sets and quick openers in the passing game.
My predictions per above: Higbee will play a bigger role both as a blocker and receiver. The wideouts will be busy confusing and breaking coverage on quick-developing plays against the 49er secondary. Stafford will be getting rid of the ball most of the time in two seconds or less. Williams will be in the game for the majority of snaps (regardless whether he starts or not - Akers may still get that nod) for pass protection. He's the best I've seen since Faulk.
The elevation of Freeman may mean more two back sets - we'll see.
We'll try to win the time of possession battle by grinding it out in the 49ers face. Higbee will be part of that.