Seems like backfield defenders were out of place constantly, the run D was not any better even with Wagner, but the safety and corner play was horrendous. I am not sure what is going on but it seems like the defense needs to get on the same page and get it together.
Yes the offense seemed off too, and yes the defense had three takeaways in the first half that the offense squandered, but when you cannot get a single third down stop, and first down and TDs play often came to guys wide open, with misaligned help and messed up assignments it was painful. This better get fixed quick because you cannot have a defense that does not trust each other.