The reasons Snead gives in this article are why I also don't see it making sense to splurge on a top 5 RB that requires pick 52. If you're using your highest draft resource to draft a RB that is superior to Henderson, then you probably have created a situation where you're not going to do a RB by committee approach. Last year's 3rd round pick, which they traded up for, gets pushed to the background and wasted. And 4 years from now, you'll be so reliant on a bell-cow that you're tempted to pay him big money.
Nah, I see them using a 3rd at most and likely a 4th round pick on someone like Zach Moss to complement Henderson.