Agreed - although we've seen McVey's reluctance to put rookies in before he's convinced they're ready - and in a game against the Bills I wouldn't expect it.
If Van isn't 100%, I'd expect Tutu from the redzone back except when down-distance dictated otherwise, and Skow the rest of the time. I'll be real interested over the course of the season to see whether position coaching and extra time with jugs machine and live fire have improved Skow's hands significantly.
I remember one WR who came into the game with all sorts of promise, except for his hands. He worked - hard - to improve that part of his game. I loved him as a player despite who he played for: Jerry Rice. Not comparing Rice with Skow in any other aspect, but it can be done.