The worst win was last year against the Patriots. I don't know about the worst lost, but that Patriots win last year was the most negative moment since Coach McVay has been with the team. It was fools gold to think in modern NFL, you can run it, punt it, and just dominate on defense. There are too many good offensive teams that will at some point make plays.
I am hoping that was out of necessity because Goff lost his mojo and the offensive line couldn't pass protect and we will get back to Kupp and Woods running after the catch in the secondary which was the bread and butter.
The best win of the season was the Tampa win. That was the blueprint on how you win in today's NFL and the strange thing is that Tampa went on to win the superbowl.