Yeah and I think their biggest prob is the clash of styles between Brady and Arians. That is where Brady's fast processing works against him, as the guy was wired for his entire career to get the ball out fast by Belichick's defensive mindset, however Arians wants him to aggressively throw the ball further down the field which means reading and disregarding guys too quickly is a bad thing.
Queue up the 22 for their big loss vs the Saints and watch that first pass play (it's a short dump left for a handful of yards). Brady reads right to left and makes the dump extremely fast on his last read, but as he throws it you can see Brown is open in the seam of the coverage for what would have been a problem for the Saints if that ball is on time and on target.
Also irt the RB outlets one of their probs is the focus of the offense doesn't enable good result. We see an example in that same game the very next play which is a dump to Jones in the right flat. He's got Evans out front (big and strong WR) who allows a DB to manhandle him while he looks back for the RB. That play I think demonstrates another issue they have, which is their wideouts don't block like ours do. When you're blocking out front you don't try to gauge where the runner is, you make your block and let him do his job. That demonstrates what is well known, which is that Arians' focus with his wideouts is double moves and gaining separation above all else.
But I agree with you on our secondary being able to limit these guys. The biggest potential problem I see is they do have the depth of talent at wideout to isolate and burn our third corner. So of course the defense will be tested and they're going to need to stop Jones on the ground because third and short it is very hard to stop Brady.