In the Rams' 3-4, you'd have 4 primary players in the DL rotation: Donald, Kobie Turner, Poona Ford and Braden Fiske.
Myles Garrett will also likely sometimes line up as one of the 3 DL (with Byron Young and Josaiah Stewart as the OLB/EDGE rushers).
Add to that some others who will likely get snaps, such as Tyler Davis, Ty Hamilton, Tim Keenan and Larrell Murchison.
It could take some time to find the best way to rotate these players to maximize their effectiveness.
So, for me, best case scenario is that Donald plays the full year and that, by the time the playoffs roll around, the rotation is perfected.